Bulletin of Experimental Biology and Medicine 2012-12-01

Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.

E S Tanigina, A V Semenikhina, T N Popova, L V Matasova, E D Kryl'skiy

Index: Bull. Exp. Biol. Med. 154(2) , 192-5, (2012)

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Abstract

Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in the blood serum. This agent also decreased the intensity of free radical processes and had a normalizing effect on aconitase activity in the heart and blood serum of rats with myocarditis.