European Journal of Medicinal Chemistry 2004-07-01

QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents.

Vijay K Agrawal, Shahnaz Bano, Claudiu T Supuran, Padmakar V Khadikar

Index: Eur. J. Med. Chem. 39(7) , 593-600, (2004)

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Abstract

Quantitative structure-activity-relationship (QSAR) study on aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl carbonic anhydrase (CA) inhibitors has been carried out topologically using first-order valence connectivity index ((1)chi(v)). Excellent results are obtained against all the three isozymes; CA I, II and IV of the zinc enzyme CA by using indicator parameters along with (1)chi(v).