Tetrahedron Letters

Copper-catalyzed cyclization of Z-oximes into 3-methyl-1, 2-benzisoxazoles

S Udd, R Jokela, R Franzén, J Tois

Index: Udd, Sandra; Jokela, Reija; Franzen, Robert; Tois, Jan Tetrahedron Letters, 2010 , vol. 51, # 7 p. 1030 - 1033

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Citation Number: 11

Abstract

1,2-Benzisoxazoles are motifs present in a wide range of pharmaceutically potent agents, including diuretics, 1 acetylcholinesterase inhibitors, 2 antileptics, 3 and neuroleptics. 4 As a result, several approaches have been developed to obtain these heterocycles. 5 Despite the diversity of existing methods only two are frequently used to access 3-substituted-1,2-benzisoxazoles (Fig. 1). ... Synthetic routes to 1,2-benzisoxazoles. Synthetic routes to 1,2-benzisoxazoles.