A Biocatalytic Route to Enantiomerically Pure Unsaturated α??H?螃窿?Amino Acids

…, KCMF Tjen, B Kaptein, QB Broxterman…

Index: Wolf, Larissa B.; Sonke, Theo; Tjen, Kim C. M. F.; Kaptein, Bernard; Broxterman, Quirinus B.; Schoemaker, Hans E.; Rutjes, Floris P. J. T. Advanced Synthesis and Catalysis, 2001 , vol. 343, # 6-7 p. 662 - 674

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Citation Number: 44

Abstract

Abstract A set of both enantiomeric forms of non??proteinogenic, unsaturated α??H?螃窿?amino acids was efficiently synthesized using a biocatalytic pathway. This route involved the straightforward synthesis of the required unsaturated amino acid amides, followed by resolution with an aminopeptidase present in Pseudomonas putida ATCC 12633 and/or a genetically modified organism, leading to the (S)??acids and (R)??amides. Undesired amino ...