Bioorganic & Medicinal Chemistry Letters 2007-01-15

Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer.

Min Wang, Gabrielle Lacy, Mingzhang Gao, Kathy D Miller, George W Sledge, Qi-Huang Zheng

Index: Bioorg. Med. Chem. Lett. 17(2) , 332-6, (2007)

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Abstract

Aromatase is a particularly good target in the treatment of estrogen receptor positive breast cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([11C]3a-f, alkyl=propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast cancer.