Nature Protocols 2007-01-01

Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor.

A James Link, Mandy K S Vink, David A Tirrell

Index: Nat. Protoc. 2 , 1884-1887, (2007)

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Abstract

This protocol describes a synthetic route to the non-canonical amino acid azidohomoalanine (AHA) using protected homoserine as a starting material. An alternative route to AHA is presented in a companion paper. This synthesis can be completed in 5 days.