Direct ortho??Arylation of N??Phenacylpyridinium Bromide by Palladium??Catalyzed C H??Bond Activation

J Xu, G Cheng, D Su, Y Liu, X Wang…

Index: Xu, Jimin; Cheng, Guolin; Su, Deyong; Liu, Yantao; Wang, Xinyan; Hu, Yuefei Chemistry - A European Journal, 2009 , vol. 15, # 47 p. 13105 - 13110

Full Text: HTML

Citation Number: 1

Abstract

Abstract A novel palladium catalyzed direct ortho-arylation of N-phenacylpyridinium bromide was developed. The amazing N-phenacyl group regioselectively activates the C [BOND] H bond of pyridine and automatically departs from the arylated products. A kinetic isotope effect study proved that the reaction went through a C [BOND] H-bond activation pathway and 2, 6-diphenylpyridine was produced stepwise from 2-phenylpyridine.