Journal of Medicinal Chemistry 1992-09-04

Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction.

S Goldmann, J Stoltefuss, L Born

Index: J. Med. Chem. 35(18) , 3341-4, (1992)

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Abstract

The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.