Syntheses of optically active α-amino nitriles by asymmetric transformation of the second kind using a principle of O. Dimroth

NA Hassan, JC Jochims

Index: Hassan, Nasser A.; Bayer, Erwin; Jochims, Johannes C. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3747 - 3757

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Citation Number: 3

Abstract

A mixture of solids As and Bs in equilibrium with the dissolved compounds A1 and B1 is transformed completely into one pure solid, say Bs, if the dissolved compounds A1⇌ B1 are equilibrating in solution. This is applied to transform 1∶ 1 mixtures of solid diastereomeric amygdalates (2-hydroxy-2-phenylacetates; mandelates)(R, R)-3+(S, R)-3 prepared from racemic α-amino nitriles (R, S)-1 with (R)-mandelic acid 2 into stereochemically pure ...