Peptidyl N-nitrosoanilines: A novel class of cysteine protease inactivators

Z Guo, J Ramirez, J Li, PG Wang

Index: Butler,R.N. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 386 - 389

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Citation Number: 24

Abstract

... Journal ... Formation of the S-NO bond in papain is supported by several lines of evidences from both spectroscopic studies and chemical analyses. ... Scheme 1. Synthetic Approach toward Compounds 6 and 7 a. a (a) EDC, HOBt, Et 3 N, CH 2 Cl 2 . (b) NaNO 2 , MeOH/HOAc, 0 °C. ...