RSC Advances

Divergent reactivities of o-haloanilides with CuO nanoparticles in water: a green synthesis of benzoxazoles and o-hydroxyanilides

N Khatun, S Guin, SK Rout, BK Patel

Index: Khatun, Nilufa; Guin, Srimanta; Rout, Saroj Kumar; Patel, Bhisma K. RSC Advances, 2014 , vol. 4, # 21 p. 10770 - 10778

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Citation Number: 13

Abstract

In the present study, three divergent reaction paths emerged when o-haloanilides were subjected to CuO nanoparticles in water. o-Halo (I, Br) phenylbenzamides in the presence of CuO nanoparticles and Cs2CO3 in water at 100° C provided o-hydroxyphenyl benzamides as the major product. However, a complete change in selectivity was observed in the presence of an organic base/ligand (TMEDA), giving 2-arylbenzoxazole as the exclusive ...