Journal of chromatography. B, Biomedical applications 1994-11-18

Detection and identification of famprofazone and its metabolite in human urine.

H S Shin, J S Park, P B Park, S J Yun

Index: J. Chromatogr. B, Biomed. Appl. 661(2) , 255-61, (1994)

Full Text: HTML

Abstract

Detection and identification of famprofazone and its metabolite, p-hydroxydesmethylfamprofazone, were described. The identity of the new metabolite was confirmed by comparing its mass spectrum and gas chromatographic retention time with that of the synthetic standard and its derivatives. Unchanged famprofazone was detected up to 6 h and the metabolite was detected up to 32 h in human urine after administration of famprofazone. The sum of the two compounds excreted in urine was ca. 1.5% of the dose.