Chemistry An Asian Journal 2013-02-01

Enantiospecific total synthesis of (-)-bengamide E.

Prashant K Metri, Raphael Schiess, Kavirayani R Prasad

Index: Chem. Asian J. 8(2) , 488-93, (2013)

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Abstract

Total synthesis of the polyhydroxy caprolactam amide natural product, bengamide E, is accomplished starting from tartaric acid. Key reactions in the synthesis include desymmetrization of the bis(dimethylamide) unit of tartaric acid, Zn(BH(4))(2)-mediated anti-selective reduction, and a Horner-Wadsworth-Emmons olefination.Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.