Farmakologiia i toksikologiia 1980-01-01

[Action of convallotoxin on cardiac hemodynamics in experimental stenosis of the pulmonary trunk].

S B Frantsuzova, L I Antonenko, L I Rytikova

Index: Farmakol. Toksikol. 43(6) , 674-9, (1980)

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Abstract

The effect of convallotoxin on hemodynamics of the right and left ventricles and pressure in the pulmonary artery was studied in intact dogs and in surgical stenosis of the pulmonary trunk. In intact anesthetized dogs, convallotoxin produced changes in hemodynamics that were more pronounced in the right than in the left ventricle (decreased intraventricular pressure, increased dp/dtmax and dp/dtmin). Administration of convallotoxin ton dogs one month after pulmonary trunk stenosis without episodes of congestive heart failure did not improve the cardiohemodynamics.