Folia Histochemica et Cytobiologica 2012-01-01

Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.

Alina Minarowska, Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko

Index: Folia Histochem. Cytobiol. 50(1) , 20-4, (2012)

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Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).