Journal of Inorganic Biochemistry 2006-07-01

Genotoxicity and transmission electron microscopy studies of molybdocene dichloride.

Kate S Campbell, Amalanie J Foster, Carolyn T Dillon, Margaret M Harding

Index: J. Inorg. Biochem. 100(7) , 1194-8, (2006)

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Abstract

The cytotoxic effects of molybdocene dichloride (Cp(2)MoCl(2)) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp(2)MoCl(2) produced significant genotoxic damage whereby 0.2micronuclei/1000 binucleated cells were induced per muM of Cp(2)MoCl(2). Transmission electron microscopic analysis of thin-sectioned cells treated with Cp(2)MoCl(2) (300microM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.