Molecular Diversity 2010-08-01

Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water.

Mohammad A Khalilzadeh, Zinatossadat Hossaini, Samaneh Kharian

Index: Mol. Divers. 14(3) , 605-9, (2010)

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Abstract

An efficient synthesis of 2H-pyridinyl-2-butenedioate derivatives via reaction of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles in water as a solvent is described.