Clinical and experimental hypertension. Part A, Theory and practice 1984-01-01

The blood pressure and metabolic effects of 19-nor-deoxycorticosterone and 19-nor-progesterone in sheep.

C D Spence, J P Coghlan, D A Denton, C E Gomez-Sanchez, E H Mills, M A Nelson, J A Whitworth, B A Scoggins

Index: Clin. Exp. Hypertens. A. 6(9) , 1591-600, (1984)

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Abstract

The present study examines the blood pressure and metabolic effects of 5 day infusions of 19-nor-deoxycorticosterone (19-nor-DOC) and 19- nor-progesterone (19-nor-PROG) in the intact conscious sheep. Both these steroids raise blood pressure in the rat. 19-nor-DOC (5 mg/d) produced a significant increase in mean arterial pressure (MAP) of 17 mmHg on day 5 (p less than 0.001), associated with 'mineralocorticoid' effects hypokalaemia, hypernatraemia and an initial urinary sodium retention. In contrast 19-nor-PROG (5 mg/d and 50 mg/d) had no effect on MAP and displayed no 'mineralocorticoid' activity.