Toxicology Letters 1982-11-01

Metabolic fate of hexabromobenzene in rats.

G Koss, H Döring, B Würminghausen, W Koransky

Index: Toxicol. Lett. 14(1-2) , 69-77, (1982)

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Abstract

To study the metabolic fate of hexabromobenzene (HBB) in female rats, the substance was administered in oral doses of 16.6 mg/kg body weight every other day for 2 weeks and the animals' excreta were examined for metabolites. Unchanged HBB, pentabromobenzene, oxygen- and sulphur-containing metabolites were detected in feces and urine. The sulphur-containing substances contained free mercapto groups except for the presence in feces of a methylmercapto derivative. The amount of sulphur-containing metabolites was estimated to be 15 times greater than that of oxygen-containing compounds. The relative proportions of the unchanged compound and its metabolites in the excreta were about 1:4.