Tetrahedron letters

Efficient cyclopropanation of active methylene compounds. A serendipitous discovery

VR Arava, UBR Siripalli, PK Dubey

Index: Arava, Veera Reddy; Siripalli, Udaya Bhaskara Rao; Dubey, Pramod Kumar Tetrahedron Letters, 2005 , vol. 46, # 42 p. 7247 - 7248

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Citation Number: 6

Abstract

Cyclopropanation of active methylene compounds is a very useful reaction in organic synthesis. 1 and 2 In general, it is carried out using either ethylene dichloride or ethylene dibromide 3 as the alkylating agent in the presence of a strong base like sodium hydride or 50% aqueous sodium hydroxide in the presence of a phase transfer catalyst (PTC), and the yields are moderate to good. During the course of our investigations on the monomethylation of ...