Reactivity of reduced [2Fe-2S] ferredoxins parallels host susceptibility to nitroimidazoles

M Vidakovic, CR Crossnoe, C Neidre…

Index: Vidakovic, Momcilo; Crossnoe, Chetlen R.; Neidre, Christopher; Kim, Kyonghee; Krause, Kurt L.; Germanas, Juris P. Antimicrobial Agents and Chemotherapy, 2003 , vol. 47, # 1 p. 302 - 308

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Citation Number: 28

Abstract

ABSTRACT The kinetics of the electron transfer reaction between reduced [2Fe-2S] ferredoxins and select nitroimidazole antimicrobial agents is reported. The ferredoxins from the protozoan Trichomonas vaginalis and the cyanobacterium Anabaena sp. strain 7120 were studied because they are the proximal electron donors to nitroimidazoles in these two organisms with significantly different nitroimidazole susceptibilities. The rates of electron ...