Antimicrobial Agents and Chemotherapy 2005-10-01

Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

P Holzmuller, D Sereno, J-L Lemesre

Index: Antimicrob. Agents Chemother. 49(10) , 4406-9, (2005)

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Abstract

We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.