Chemical Communications 2011-04-07

Planar triazinium cations from VO(2+)-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA.

Puja Prasad, Imran Khan, Pijus K Sasmal, Debasis Koley, Paturu Kondaiah, Akhil R Chakravarty

Index: Chem. Commun. (Camb.) 47(13) , 3954-6, (2011)

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Abstract

Planar triazinium cationic species, from VO(2+)-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.