Bioorganic & Medicinal Chemistry Letters 2011-07-01

Selective accumulation of hybrid liposomes into adult T-cell leukemia cells along with induction of apoptosis.

Yuji Komizu, Mamiko Yukihara, Ryusho Kariya, Koichi Goto, Seiji Okada, Ryuichi Ueoka, Yuji Komizu, Mamiko Yukihara, Ryusho Kariya, Koichi Goto, Seiji Okada, Ryuichi Ueoka

Index: Bioorg. Med. Chem. Lett. 21(13) , 3962-5, (2011)

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Abstract

Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.Copyright © 2011 Elsevier Ltd. All rights reserved.