Haemostasis 1978-01-01

Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.

G Claeson, L Aurell, P Friberger, S Gustavsson, G Karlsson

Index: Haemostasis 7 , 62, (1978)

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Abstract

Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.