European Journal of Medicinal Chemistry 2003-01-01

New bis(pyridyl)methane derivatives from 4-hydroxy-2-pyridones: synthesis and antitumoral activity

Maria Teresa Cocco, Cenzo Congiu, Valentina Onnis, Maria Teresa Cocco, Cenzo Congiu, Valentina Onnis

Index: Eur. J. Med. Chem. 38(1) , 37-47, (2003)

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Abstract

Bis(pyridyl)methane derivatives 5– 40 were obtained from the reaction of 4-hydroxy-2-pyridones 3 and 4 with aldehydes. Compounds 5– 40 were evaluated for cytotoxic activity against a panel of 60 human cancer cell lines by the National Cancer Institute and some of them demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10 −5 M level and in some case at 10 −7 M concentrations.