Planta Medica 1989-08-01

Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.

A De Bruyn, M Verzele, J P Dejonghe, K S Bhushana Rao, M P Collard, A Trouet, J Hannart

Index: Planta Med. 55(4) , 364-6, (1989)

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Abstract

A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.