Synthesis and pharmacological activity of amino acid derivatives of nicotinic acid

EA Kuznetsova, TA Voronina, IV Khromova…

Index: Kuznetsova, E. A.; Voronina, T. A.; Khromova, I. V.; Garibova, T. L.; Tosina, E. K.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 12 p. 943 - 949 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 12 p. 1425 - 1431

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Abstract

It is well known that amino derivatives of nicotinic acid possess significant neuropsychotropic properties. In particular, the nicotinoyl derivatives of glutamic and" t- aminobutyric (GABA) acids have the properties of lowering motor excitation stimulated by phenamine, promoting the action of hexenal, and lowering motor activity; in addition, these compounds have antispasmodic action according to their antagonism to korazole, and ...