Organic & Biomolecular Chemistry 2013-09-07

Combined C-H functionalization/O-H insertion reaction to form tertiary β-alkoxy substituted β-aminophosphonates catalyzed by [Cu(MeCN)4]PF6.

Yan Cai, Yuchen Lu, Chengbin Yu, Hairong Lyu, Zhiwei Miao

Index: Org. Biomol. Chem. 11(33) , 5491-9, (2013)

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Abstract

The copper-catalyzed C-H functionalization/O-H insertion reaction of α-diazophosphonates with alcohols has been developed with iodine as an additive. In order to understand this reaction, we present here a possible mechanism for the combined reaction. This process provides straightforward access to tertiary β-alkoxy substituted β-aminophosphonate derivatives with moderate to good yields.