Zeitschrift fuer Naturforschung. Section C 2013-01-01

Cytotoxic rocaglamide derivatives from Aglaia duppereana.

Mona El-Neketi, Weaam Ebrahim, Ngoc Tu Duong, Sahar Gedara, Farid Badria, Hassan-Elrady A Saad, Werner E G Müller, Peter Proksch

Index: Z. Naturforsch., C, J. Biosci. 68(7-8) , 269-74, (2013)

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Abstract

Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cytotoxic activity against mouse lymphoma (L5178Y) cells with EC50 values ranging from 5.1 to 54.8 nM.