Journal of Chemistry

Synthesis of 3-(1, 3-Diphenyl-1H-pyrazol-4-yl) Propanoic Acids Using Diimide Reduction

M Deepa, VH Babu, R Parameshwar…

Index: Deepa; Babu, V. Harinadha; Parameshwar; Reddy, B. Madhava E-Journal of Chemistry, 2012 , vol. 9, # 1 p. 420 - 424

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Citation Number: 5

Abstract

Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H-4-yl-acrylic acids to 3-(1, 3-diphenyl-1H- pyrazol-4-yl) propanoic acids (4a-j) was carried out using Pd-charcoal and diimide methods and% yields were compared. Though the yields may be slightly less in diimide method, ...