A revision of the alcoholysis and alkanethiolysis of 3??amino??6??chloropyridazine

BUW Maes, GLF Lemière, R Dommisse…

Index: Maes; Lemiere; Dommisse; Haemers Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1215 - 1218

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Citation Number: 5

Abstract

In the literature it is well documented that the amino group of 3-amino-6-chloropyridazine (1) deactivates the C-6 position for nucleophilic attack and extreme reaction conditions are reported to perform nucleophilic aromatic substitution reactions on this skeleton [1]. In the standard literature procedure for the alcoholysis (boiling point of alcohol < 140 °C) and alkanethiolysis of 1 an autoclave is used as the reaction vessel. Recently, we described suc- cessful Suzuki and Stille ...