Applied Microbiology and Biotechnology 2011-07-01

Microbial metabolism and biotechnological production of D-allose.

Yu-Ri Lim, Deok-Kun Oh

Index: Appl. Microbiol. Biotechnol. 91 , 229-35, (2011)

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Abstract

D-allose has attracted a great deal of attention in recent years due to its many pharmaceutical activities, which include anti-cancer, anti-tumor, anti-inflammatory, anti-oxidative, anti-hypertensive, cryoprotective, and immunosuppressant activities. D-allose has been produced from D-psicose using D-allose-producing enzymes, including L-rhamnose isomerase, ribose-5-phosphate isomerase, and galactose-6-phosphate isomerase. In this article, the properties, applications, and metabolism of D-allose are described, and the biochemical properties of D-allose-producing enzymes and their D-allose production are reviewed and compared. Moreover, several methods for effective D-allose production are suggested herein.