European Journal of Biochemistry 1981-07-01

A synthetic ionophore for Ca2+: studies with model and biological systems.

B D Gomperts, J P Bennett, D Allan

Index: Eur. J. Biochem. 117(3) , 559-62, (1981)

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Abstract

We show that the relatively simple beta-diketone, 1.1.1.2.2.3.3-heptafluoro-7,7-dimethyloctane-4,6-dione, known as "fod", will solvate Ca2+ ions in an organic phase. In consequence it will transport Ca2+ across phospholipid bilayers. It acts as predicted for a Ca2+-transporting ionophore in two biological systems: it will stimulate Ca2+-dependent K+ efflux from human red blood cells, and Ca2+-dependent histamine secretion from rat peritoneal mast cells.