Journal - Association of Official Analytical Chemists 1990-01-01

Determination of thiabendazole, 5-hydroxythiabendazole, fenbendazole, and oxfendazole in milk.

S S Tai, N Cargile, C J Barnes

Index: J. Assoc. Off. Anal. Chem. 73(3) , 368-73, (1990)

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Abstract

The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10 ppb level were 80% or greater with an intralaboratory coefficient of variation of 11% or less. Recovery of 5-hydroxythiabendazole (5-OH-TBZ) at the 30 ppb level averaged 56% with an intralaboratory coefficient of variation of 5%. Limited data on the depletion of FBZ, OFZ, TBZ, and 5-OH-TBZ in milk were also generated.