FEBS Letters 1990-09-17

Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid.

S A Rabia, E Fibach, M Kotler, S Gatt

Index: FEBS Lett. 270(1-2) , 9-10, (1990)

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Abstract

Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the virus, resulting in a drastic decrease of its infectivity. The virus inactivation was proportional to the concentration of the pyrene-fatty acid, the length of exposure of the virus to P12 and the irradiation dose.