Journal of Pharmaceutical and Biomedical Analysis 2001-08-01

Application of reinecke salt and alizarin S for the determination of promazine.

H Puzanowska-Tarasiewicz, L Kuźmicka, E Kleszczewska

Index: J. Pharm. Biomed. Anal. 26(1) , 1-5, (2001)

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Abstract

Reinecke salt and alizarin S have been tested as reagents for the determination of promazine. They react in neutral and acidic media with promazine forming a reddish and brown crystalline compounds. The compounds are sparingly soluble in water but fairly soluble in acetone and methanol. The quantitative extraction of compound of promazine with alizarin S has been used for the extractive spectrophotometric determination of promazine. Formation of promazine ion-association complex with Reinecke salt has been applied for indirect determination of low concentrations of promazine by AAS measurement of the chromium content of the reineckate counter - anion.