Organic Letters 2006-12-07

Nonenzymatic oligomerization of RNA by TNA templates.

Benjamin D Heuberger, Christopher Switzer

Index: Org. Lett. 8(25) , 5809-11, (2006)

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Abstract

Cytosine TNA promotes nonenzymatic, template-directed oligomerization of complementary activated rGMP, leading to selective and efficient formation of RNA products. This process models "genetic takeover" of a pre-RNA by RNA. [reaction: see text]