cis-4-[[[(2-Chloroethyl) nitrosoamino] carbonyl] methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor

…, GS McCaleb, WC Rose, JA Montgomery

Index: Johnston; McCaleb; Rose; Montgomery Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 97 - 99

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Citation Number: 9

Abstract

Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255- 5305. Received June 20, 1983 cis-4-[[[(2-Chloroethyl) nitrosoamino] carbonyl] methylamino] cyclohexanecarboxylic acid (N-Me-cis-CCCNU) was synthesized in five steps from cis-4- aminocyclohexanecarboxylic acid via an N-tosylated intermediate. N-Mecis-CCCNU, which is incapable of the facile decomposition that characterizes the clinically useful ...