Chemical & Pharmaceutical Bulletin 2015-01-01

An improved efficient synthesis of the antibacterial agent torezolid.

Gang Li, Bao-Kun Yuan, Wu Tang, Hong-Yi Zhao, Zi-Yun Lin, Hai-Hong Huang

Index: Chem. Pharm. Bull. 63(2) , 143-6, (2015)

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Abstract

An improved and efficient method for the preparation of torezolid based on Suzuki cross-coupling reaction as the key step was developed on a gram scale in five steps. The total yield was 44% and the optical purity of torezolid by the improved method was above 99%.