Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoi i mikrobiologicheskoi promyshlennosti SSSR 1988-01-01

[Isolation of 5-benzyl hydroxytryptophan enantiomers by using microbial aminoacylase].

L T Kushashvili, A K Zhuravlev, A G Borodkin, G V Popova, A D Nekliudov

Index: Antibiot. Khimioter. 33(1) , 16-22, (1988)

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Abstract

The process of asymmetric deacylation of an acetyl derivative of 5-benzyl hydroxytryptophan racemate in the presence of native microbial aminoacylase was studied. The effect of pH, temperature, concentration of the enzyme and substrate were investigated. Conditions for preparation and isolation of individual amino acids were defined by optimization of N-Ac-DU-5-BOT hydrolysis.