Tetrahedron

Palladium-catalyzed direct arylation of thiazoles with aryl bromides

A Yokooji, T Okazawa, T Satoh, M Miura, M Nomura

Index: Yokooji, Aya; Okazawa, Toru; Satoh, Tetsuya; Miura, Masahiro; Nomura, Masakatsu Tetrahedron, 2003 , vol. 59, # 30 p. 5685 - 5689

Full Text: HTML

Citation Number: 136

Abstract

Thiazole, 2-phenyl or-alkyl substituted one and benzothiazole are efficiently arylated with aryl bromides at the 2-and/or 5-position (s) in the presence of Pd (OAc) 2 and a bulky phosphine ligand using Cs2CO3 as base. 2-Phenyl-5-thiazolecarboxanilide undergoes successive diarylation at the 4-and 5-positions accompanied by decarbamoylation.