Australian and New Zealand Journal of Obstetrics and Gynaecology 2013-08-01

Clomiphene ovulation induction and higher-order multiple pregnancy.

Simon McDowell, Ben Kroon, Anusch Yazdani

Index: Aust. N. Z. J. Obstet. Gynaecol. 53(4) , 395-8, (2013)

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Abstract

Clomiphene citrate is a widely used treatment for ovulatory dysfunction in women seeking pregnancy. The major adverse consequence of clomiphene use is the increased risk of multiple and higher-order multiple pregnancy. Mechanisms for multiple pregnancy include dosing variation, adjuvant therapies, pretreatment weight loss and a cumulative effect of multiple clomiphene cycles. It has been suggested that the risk of higher-order multiple pregnancy may be reduced with ultrasound monitoring, although there is limited evidence to support this practice. © 2013 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.