European Journal of Pharmaceutical Sciences 2010-01-01

Regional absorption of fexofenadine in rat intestine

Caroline MacLean, Ulla Moenning, Andreas Reichel, Gert Fricker

Index: Eur. J. Pharm. Sci. 41(5) , 670-4, (2010)

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Abstract

Purpose Expression of Pgp along the GI-tract of rats increases towards distal segments. We assessed the in vivo relevance by determining the absorption of fexofenadine from proximal and distal parts of rat intestine. Since it has been reported that fexofenadine is also actively taken up by OATP/oatps, we quantified rat oatp1a5 and oatp2b1 mRNA in gut mucosa to elucidate a possible contribution of an oatp-mediated active uptake of fexofenadine.