International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 1992-04-01

m-[125I]iodoaniline: a useful reagent for radiolabeling biotin.

L A Khawli, A I Kassis

Index: Int. J. Rad. Appl. Instrum. B 19(3) , 297-301, (1992)

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Abstract

Biotinyl-m-[125I]iodoanilide (BIA) was synthesized by coupling biotin to m-[125I]iodoaniline via a mixed anhydride reaction. m-[125I]Iodoaniline was produced from the tin precursor, which was prepared using a palladium catalyzed reaction of hexabutylditin with m-bromoaniline. The radioiodinated BIA derivative is characterized by a stable amide and/or intact ureido group on the biotin molecule; it may thus be a useful carrier for targeting radionuclides to avidin-conjugated antibodies previously localized on tumors.