Organic Letters 2001-09-06

Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.

Y Yu, J M Ostresh, R A Houghten

Index: Org. Lett. 3(18) , 2797-9, (2001)

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Abstract

[reaction: see text]. The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, provided the corresponding triazepane-2,4-diones.