Bioorganic & Medicinal Chemistry 2013-04-01

6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Ashish K Pathak, Vibha Pathak, Lainne E Seitz, William J Suling, Robert C Reynolds

Index: Bioorg. Med. Chem. 21(7) , 1685-95, (2013)

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Abstract

6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate to good inhibitory activity. N(9)-substitution apparently enhances the anti-mycobacterial activity in the purine series described herein. Several 2-amino and 2-chloro purine analogs were also synthesized that showed moderate inhibitory activity against Mtb.Copyright © 2013 Elsevier Ltd. All rights reserved.