Journal of the American Chemical Society 2012-10-17

Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.

Jukuan Zheng, Kaiyi Liu, Darrell H Reneker, Matthew L Becker

Index: J. Am. Chem. Soc. 134(41) , 17274-7, (2012)

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Abstract

A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.