Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2004-04-29

Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols.

Ali Reza Harifi-Mood, Saeed Haghighi, Mohammad Reza Gholami

Index: J. Pharm. Pharm. Sci. 7(1) , 88-91, (2004)

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Abstract

Variable-Temperature Kinetics has been used to obtain the rate constants of the reaction at various temperatures during one kinetic run.Pseudo-first-order rate constants for the transesterification of procaine with aliphatic alcohols ethanol, n-propanol and tert-butanol were obtained by the fluorescence spectroscopy using the variable-temperature kinetics (VTK) method.The activation parameters of the reactions were calculated (24-28 kcal x mol(-1)). The half-life of the procaine decreases in the ethanol solution compared with the other alcoholic solutions in the presence of sodium ethoxide.The investigation time of the reactions is reduced to one-tenth of the one used for usual kinetic methods.