Molecular Brain Research 1998-01-01

Inhibition of lysophosphatidic acid-induced neurite retraction and cell rounding by SR 57746A.

M Magazin, P Schiltz, J L Zachayus, E Cavrois, D Caput, P Ferrara

Index: Brain Res. Mol. Brain Res. 53(1-2) , 301-6, (1998)

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Abstract

Rapid neurite retraction and transient rounding of serum-starved NG108-15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and reduced by pre-incubation of the cells with the small non-peptidic molecule, SR 57746A, which exhibits neurotrophic properties. The compound also antagonizes the redistribution of filamentous actin by LPA in both cell types. We hypothesize that the SR 57746A attenuation of LPA-induced effects may account for at least some of the neuroprotective properties of this molecule.